Presenter: J.-P. Marie
Jean-Pierre Marie met hematology for the first time in 1976, as resident in Hôtel-Dieu hospital in Paris. Since this date, his career was devoted to onco-hematology. He spent 6 month in Mc Culloch lab in 1980, to learn leukemic cells culture, and came back to Hôtel-Dieu as Chef de Clinique, Associate professor and professor, in the department of his mentor, Prof Robert Zittoun, in Hôtel-Dieu of Paris. He spent one year in Stanford in 1988-89, in the laboratory of oncology (BI Sikic), working on drug resistance through ABC proteins. He published the first papers on P-gp and drug resistance in acute myeloid leukemia. Since these years, his main focus on research is resistance to chemotherapy in haematological malignancies, especially AML. His research lab (Team 18, UMRs872 University P & M Curie, created in 1999) is devoted to this subject (ABC proteins, micro-environment, anti-apoptotic signals). Head of the hematology laboratory of Hôtel-Dieu from 1993 to 1998, he led the Department of hematology and medical oncology from 1999 to 2010, until he moved with his staff to Hospital Saint-Antoine, Paris. As member (1978-1997), secretary (1998-2004), chairman elect (2005-2008) and chairman (2009-2011) of the EORTC Leukemia Group, he participated to all AML, ALL and MDs trials of this group.