DEBATE: Does chronic venous insufficiency play a role in MS pathogenesis? YES SEE also CON POSITION and COMMENTARY Etiology and Pathogenesis of MSOctober 30, 2010 11:10
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|Congress:||The 4th World Congress on Controversies in Neurology (CONy)|
Chronic cerebrospinal venous insufficiency (CCSVI) is a syndrome characterized by flow blockages in the internal jugular and/or azygous veins (IJVs-AZ) with opening of collaterals and insufficient drainage proved by reduced cerebral blood flow and increased mean transit time in cerebral MRI perfusional study. As far as the origin of venous narrowing is concerned, phlebographic studies of the IJVs and AZ systems demonstrated that venous stenoses were likely to be truncular venous malformations. CCSVI condition has been found to be strongly associated with multiple sclerosis (MS), a disabling neurodegenerative and demyelinating disease considered autoimmune in nature. In several epidemiological observations performed at different latitudes on patients with different genetic backgrounds the prevalence of CCSVI in MS ranges from 56% to 100%. In this particular moment the status of the research cannot clarify at all if CCSVI should play a role in MS pathogenesis. There are 3 main research fields producing findings partially supporting this idea.
|Category:||Neurology; Multiple Sclerosis; pathogenesis;|
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